Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect) ,and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of 20.26 mmol/l per A-allele/protein unit (95% CI 20.38, 20.14, P=0.000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.

Original publication

DOI

10.1017/S0007114512006058

Type

Journal article

Journal

Br J Nutr

Publication Date

14/09/2013

Volume

110

Pages

790 - 796

Keywords

Activating Transcription Factor 6, Adult, Cholesterol, HDL, Dietary Proteins, Fatty Acid-Binding Proteins, Female, Gene Expression Regulation, Glycemic Index, Humans, Lipid Metabolism, Lipids, Lipoprotein Lipase, Male, Nuclear Proteins, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Phosphatidate Phosphatase, Polymorphism, Single Nucleotide, Transcription Factors