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BACKGROUND: We previously reported an association between 5HTTLPR genotype and outcome following cognitive-behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive outcomes. Other similar studies have produced mixed results, with most reporting no association between genotype and CBT outcome. AIMS: To replicate the association between 5HTTLPR and CBT outcome in child anxiety from the Genes for Treatment study (GxT Cohort 2, n = 829). METHOD: Logistic and linear mixed effects models were used to examine the relationship between 5HTTLPR and CBT outcomes. Mega-analyses using both cohorts were performed. RESULTS: There was no significant effect of 5HTTLPR on CBT outcomes in Cohort 2. Mega-analyses identified a significant association between 5HTTLPR and remission from all anxiety disorders at follow-up (odds ratio 0.45, P = 0.014), but not primary anxiety disorder outcomes. CONCLUSIONS: The association between 5HTTLPR genotype and CBT outcome did not replicate. Short-allele homozygotes showed more positive treatment outcomes, but with small, non-significant effects. Future studies would benefit from utilising whole genome approaches and large, homogenous samples.

Original publication

DOI

10.1192/bjp.bp.114.154997

Type

Journal article

Journal

Br J Psychiatry

Publication Date

02/2016

Volume

208

Pages

182 - 188

Keywords

Adolescent, Alleles, Anxiety Disorders, Child, Child, Preschool, Cognitive Behavioral Therapy, Female, Gene-Environment Interaction, Genotype, Humans, Male, Psychiatric Status Rating Scales, Remission Induction, Serotonin Plasma Membrane Transport Proteins, Treatment Outcome