Identification of a new locus at 16q12 associated with time to asthma onset.
Sarnowski C., Sugier P-E., Granell R., Jarvis D., Dizier M-H., Ege M., Imboden M., Laprise C., Khusnutdinova EK., Freidin MB., Cookson WOC., Moffatt M., Lathrop M., Siroux V., Ogorodova LM., Karunas AS., James A., Probst-Hensch NM., von Mutius E., Pin I., Kogevinas M., Henderson AJ., Demenais F., Bouzigon E.
BACKGROUND: Asthma is a heterogeneous disease in which age of onset plays an important role. OBJECTIVE: We sought to identify the genetic variants associated with time to asthma onset (TAO). METHODS: We conducted a large-scale meta-analysis of 9 genome-wide association studies of TAO (total of 5462 asthmatic patients with a broad range of age of asthma onset and 8424 control subjects of European ancestry) performed by using survival analysis techniques. RESULTS: We detected 5 regions associated with TAO at the genome-wide significant level (P